Details of Mary's birth are not known.

Mary married James Ambrose in 1748 in Wigan, Lancashire on 19th November 1748.

She had the following children from her marriage to James Ambrose:

- Margaret Ambrose	born around 1749.
- Ellis Ambrose	born around 1750.
- Mary Ambrose	born around 1753.
- Hannah Ambrose	born around 1755.
- Martha Ambrose	born around 1757.
- John Ambrose	born around 1759.
- Jane Ambrose	born around 1761.
- Alice Ambrose	born around 1764.
- Ann Ambrose	born around 1766.