William Derbyshire was born around 1869 in Warrington, Lancashire.

William married Clara Elizabeth Anderton in 1893 in Warrington, Lancashire.

He had the following children from his marriage to Clara Elizabeth Anderton:

- Ernest Derbyshire	born around 1894 in Warrington, Lancashire.
- William Derbyshire	born around 1896 in Warrington, Lancashire.
- Ada Derbyshire	born around 1900 in Warrington, Lancashire.
- Elizabeth Derbyshire	born around 1904 in Warrington, Lancashire.

William was an Engine driver.

Details of William's death are not known.