Jessie MacDuff was the daughter of Joseph MacDuff and Henrietta Lavender.

Jessie was born on Sunday 17 March 1889 in Cambuslang, Lanarkshire, Scotland.

Jessie married William Towell

Details of Jessie's marriage are not known.

She had the following children from her marriage to William Towell:

- Jean Rairety Towell	born on 16 August 1911 in Motherwell, Scotland.
- Joseph MacDuff Towell
- Henrietta Lavender Towell

Jessie's second marriage was to William Cook

Details of Jessie's marriage are not known.

She had the following children from her marriage to William Cook:

- Jessie MacDuff Cook	born in 1924 (date suppressed).
- Doris Adams Cook	born in 1927.

Jessie died when she was 65 years old, on Thursday 23 September 1954.